Microengineering for biomedical applications
竹内 昌治 教授
Here, I am planning to talk about several MEMS/Microfluidic-based approaches for various biomedical applications including implantable monitoring and tissue engineering.
Fluorescent hydrogels hold great promise for in vivo continuous glucose monitoring with wireless transdermal transmission and long-lasting activity. We synthesized a highly-sensitive fluorescent monomer, and then fabricated injectable-sized fluorescent polyacrylamide hydrogel beads and fibers with high uniformity and high throughput. We find that the fluorescent beads/fibers provide sufficient intensity to transdermally monitor glucose concentrations in vivo.
Macroscopic 3D tissue architectures are important for not only in tissue engineering but also drug testing. We demonstrated a construction method of 3D tissue structures by using cell beads and cell fibers. For example, a cell-encapsulating core-shell hydrogel fiber was used for constructing fiber-based tissues including muscles, nerves and blood vessels. Moreover, the fiber encapsulating beta-cells is used for the implantation of diabetic mice, and succeeded in normalizing the blood glucose level.